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Cat. No. | Product Name | Target | Signaling Pathways |
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T80052 |
Cathepsin B
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Cathepsin B为一种半胱氨酸蛋白酶,涉及多种程序性细胞死亡(包括细胞凋亡、焦亡、铁亡、坏死亡及自噬性细胞死亡)。 | |||
T3420 |
CA-074 methyl ester
Cathepsin B Inhibitor IV,CA-074Me |
Cysteine Protease | Proteases/Proteasome |
CA-074 methyl ester (Cathepsin B Inhibitor IV) 是Cathepsin B 的选择性抑制剂,具有保护神经、抗炎、抗癌等多种作用。 | |||
T27989 |
MDK0734
Cathepsin B Inhinitor-42 |
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MDK0734 is a selective inhibitor of cathepsin B endopeptidase and exopeptidase activities. | |||
T28003 |
MDK7677
Cathepsin B Inhinitor-17,MDK 7677 |
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MDK7677 is a selective inhibitor of cathepsin B endopeptidase and exopeptidase activities. | |||
T10924 |
Cysteine protease inhibitor-2
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Cysteine Protease | Proteases/Proteasome |
Cysteine protease inhibitor-2 是半胱氨酸蛋白酶抑制剂。 | |||
T6015 |
Cathepsin Inhibitor 1
|
Cysteine Protease | Proteases/Proteasome |
Cathepsin inhibitor 1 是Cathepsin 的选择性抑制剂,能够抑制CatL(pIC50:7.9)、CatL2(pIC50:6.7)、CatS(pIC50:6.0)、CatK(pIC50:5.5)和CatB(pIC50:5.2)。 | |||
T21509 | CA 074 | Cysteine Protease | Proteases/Proteasome |
CA 074 是一种高效的组织蛋白酶B (cathepsin B) 抑制剂, Ki 值为2 to 5 nM。CA 074 抑制灵长类动物缺血性海马神经元死亡,可减轻 SJL/J 小鼠诱导的实验性自身免疫性脑脊髓炎的视网膜病变和视神经炎。 | |||
T13288 |
VBY-825
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Cysteine Protease | Proteases/Proteasome |
VBY-825是cathepsin 一种新型的可逆抑制剂,对cathepsin B, L, S 和V 都有很高的抑制力。 | |||
T16089 |
MK-0674
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Cysteine Protease | Proteases/Proteasome |
MK-0674 是一种可口服且具有选择性和高效性的 cathepsin K 抑制剂(IC50:0.4 nM),抑制 Cat B、Cat F、Cat L 和 Cat S,可用于和代谢相关的疾病。 | |||
T37504L |
Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)
Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base) |
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Cathepsin D and E FRET Substrate acetate 是组织蛋白酶 D 和 E 的荧光底物,但不适用于 B、H 或 L。Cathepsin D and E FRET Substrate acetate 可用于组织蛋白酶 D 和 E 研究的机理研究。 | |||
T1850 |
Balicatib
AAE581,巴利卡替 |
Cysteine Protease | Proteases/Proteasome |
Balicatib (AAE581) 是组织蛋白酶K 抑制剂,其对组织蛋白酶K 的抑制作用是组织蛋白酶B、L 和S 的抑制性的10到100倍。 | |||
T15641 |
K777
APC-3316 |
P450; Cysteine Protease; CCR | Immunology/Inflammation; Metabolism; Microbiology/Virology; Proteases/Proteasome |
K777 是有效的,具有口服活性的,不可逆的半胱氨酸蛋白酶 (cysteine protease) 抑制剂。K777是有效的 CYP3A4 抑制剂(IC50= 60 nM)。K777也是选择性的 CCR4 拮抗剂,显示出强的趋化性抑制作用。K777 对 Cruzain(克鲁斯锥虫的主要半胱氨酸蛋白酶)和组织蛋白酶 B 和 L 具有不可逆的抑制作用。K777 通过靶向组织蛋白酶介导的细胞进入,显示出广谱的抗病毒作用。K777 抑制 EBOV 和 SARS-CoV 病毒的进入,IC50 值分别为 0.87 nM 和 0.68 nM。 | |||
T16092 |
L-873724
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Others | Others |
L-873724 inhibits bone resorption. L-873724 is an effective, selective, and reversible non-basic cathepsin K inhibitor (IC50s: 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively). L-873724 also shows an IC50 of | |||
T37053 |
Z-(L-Arg)-AMC (hydrochloride)
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Z-(L-Arg)-AMC is a fluorogenic substrate for trypsin, cathepsin B, and cathepsin H.1,2Upon enzymatic cleavage by trypsin, cathepsin B, or cathepsin H, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify trypsin, cathepsin B, and cathepsin H activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. 1.Zimmerman, M., Ashe, B., Yurewicz, E.C., et al.Sensitive assays for trypsin, elastase, and chymotrypsin using new fluorogenic substrat... | |||
T80739 |
Z-FG-NHO-BzOME
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Z-FG-NHO-BzOME 是一种选择性半胱氨酸蛋白酶抑制剂,主要作用于组织蛋白酶 B、组织蛋白酶 L、组织蛋白酶 S 及木瓜蛋白酶。 | |||
T78186 |
Ac-VLPE-FMK
Ac-Val-Leu-Pro-Glu(OMe)-CH2F |
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Ac-VLPE-FMK为一种四肽基单氟甲基酮(m-FMK),兼作Cat-B及Cat-L抑制剂,适用于癌症侵袭性研究。 | |||
T73220 |
RO5461111
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RO5461111 是一种高特异性、口服有效的Cathepsin S 拮抗剂 (IC50: 0.4 nM, humanCathepsin S ; 0.5 nM, murineCathepsin S)。RO5461111 能够有效抑制抗原特异性 T 细胞和 B 细胞活化。RO5461111 对肺部炎症和狼疮性肾炎有改善作用。 | |||
T76599 |
Ac-Leu-Val-Lys-Aldehyde
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Ac-Leu-Val-Lys-Aldehyde 是有效的组织蛋白酶 B (cathepsin B) 抑制剂,其 IC50 值为 4 nM。该化合物能显着降低喹啉酸引起的纹状体细胞死亡,并促使 LC3-II 积累。 | |||
T36942 |
SSAA09E1
SSAA09E1 |
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SSAA09E1 is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) viral entry.1It reduces infection of HEK293T cells transiently transfected with angiotensin-converting enzyme 2 (ACE2) by an HIV-based virus system pseudotyped with SARS-CoV surface glycoprotein (EC50= 6.7 μM). SSAA09E1 also inhibits the proteolytic activity of cathepsin L (IC50= 5.33 μM) but not cathepsin B when used at a concentration of 20 μM. 1.() | |||
TP2161 |
Z-WEHD-FMK
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Caspase | Apoptosis; Proteases/Proteasome |
Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM). | |||
T15064 |
DBCO-NHCO-PEG4-NHS ester
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Others | Others |
DBCO-NHCO-PEG4-NHS ester ester is a MMP-2- and cathepsin B- (CatB) cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | |||
T73554 | SPR38 | ||
SPR38 是一种有效的 SARS-CoV-2 主要蛋白酶 (SARS-CoV-2 main protease) 抑制剂,Ki 为 0.260 μM。SPR38 还抑制hCatL 和hCatB,Ki 值分别为 1.92 μM 和 11.1 μM。 | |||
T73553 |
SPR39
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SPR39 是一种有效的 SARS-CoV-2 主要蛋白酶抑制剂,对 SARS-CoV-2 Mpro, hCatL, hCatB 的 Ki 值分别为 0.252、3.38、7.88 µM。SPR39 具有抗病毒和细胞毒性。 | |||
T75367 |
Z-Arg-Arg-4MβNA triacetate
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Z-Arg-Arg-4MβNA triacetate 为特异性针对组织蛋白酶 B(cathepsin B)的底物,其降解后可释放荧光产物4MβNA(λex= 355 nm, λem= 430 nm)。 | |||
T62494 | Cathepsin C-IN-5 | ||
CathepsinC-IN-5 (compound SF38) 为一高效、选择性、口服活性的组织蛋白酶 C (Cat C) 抑制剂,其针对Cat C、Cat L、Cat S、Cat B、Cat K 的IC50s 分别为 59.9 nM、4.26 µM、>5 µM、>5 µM、>5 µM。该化合物能够抑制骨髓和血液中的Cat C活性,降低中性粒细胞丝氨酸蛋白酶(NSP)的激活,并展现抗炎活性。 | |||
T6564L |
Leupeptin
Leupeptin Ac-LL,NK-381 |
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Leupeptin is a competitive protease inhibitor produced by actinomycetes. Leupeptin can inhibit cysteine, serine and threonine peptidases. Leupeptin inhibits serine proteinases (trypsin (Ki=3.5 nM), plasmin (Ki= 3.4 nM), porcine kallikrein), and cysteine p | |||
T11864 |
Iptacopan
LNP023 |
Others | Others |
Iptacopan (LNP023) 是一种与factor B 亲和力较高的抑制剂。 | |||
T69297 | Leupeptin HCl | ||
Leupeptin is a naturally occurring protease inhibitor that can inhibit cysteine, serine and threonine peptidases. Leupeptin is an organic compound produced by actinomycetes. Leupeptin inhibits serine proteinases (trypsin (Ki=3.5 nM), plasmin (Ki= 3.4 nM), porcine kallikrein), and cysteine proteinases (papain, cathepsin B (Ki = 4.1 nM), endoproteinase Lys-C). It does not inhibit α-chymotrypsin or thrombin. Leupeptin is a competitive transition state inhibitor and its inhibition may be relieved by... | |||
T21949 |
Calpain Inhibitor XII
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(Rac)-Calpain Inhibitor XII是一种可逆的,选择性抑制钙蛋白酶I(calpain I; μ-calpain)的化合物,具有19 nM的Ki值。其对钙蛋白酶II(calpain II; m-calpain; Ki=120 nM)和组织蛋白酶B(cathepsin B; Ki=750 nM)显示出较低的抑制亲和力。(Rac)-Calpain Inhibitor XII用于研究钙蛋白酶在多种生理过程中的角色,如嗜中性粒细胞趋化性、神经元信号传导和心脏对损伤的响应。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T6564 |
Leupeptin Hemisulfate
亮肽素 |
Serine Protease; Cysteine Protease | Proteases/Proteasome |
Leupeptin hemisulfate 是一种蛋白酶抑制剂,具有细胞膜渗透性、可逆性、竞争性和口服活性。Leupeptin hemisulfate 可以抑制 Cathepsin B、Cathepsin H、Cathepsin L 的活性,阻断两性溶酶体的融合。Leupeptin hemisulfate 还具有抗炎活性。 | |||
TN1249 |
3-Epiursolic acid
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Cysteine Protease; Immunology/Inflammation related | Immunology/Inflammation; Proteases/Proteasome |
3-Epiursolic Acid 是一种三萜类物质,分离自桃金娘科植物,是组织蛋白酶 L 的竞争性抑制剂(IC50=6.5 μM,Ki=19.5 μM),对 cathepsin B 无明显作用。 | |||
T3417 |
Amentoflavone
Didemethyl-ginkgetin,穗花杉双黄酮,Amenthoflavone,3',8''-Biapigenin |
Apoptosis; P450; Phospholipase; Reactive Oxygen Species; Opioid Receptor; COX; Antibacterial; RSV; Antifungal | Apoptosis; Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; NF-κB |
Amentoflavone (3',8''-Biapigenin) 是一种具有很多生物活性的双黄酮类天然产物,有抗炎、抗氧化和神经保护等作用。 | |||
TJS2216 |
Aurantiamide acetate
金色酰胺醇酯,Asperglaucide |
Cysteine Protease | Proteases/Proteasome |
Aurantiamide acetate (Asperglaucide) 是抑制口服有活性的 cathepsin 选择性抑制剂,分离自 Portulaca oleracea L。它具有抗炎作用,可用于研究炎性相关疾病。 |